PARD6A antibody (N-Term)

Catalog No. ABIN2775615

This anti-PARD6A antibody is a Rabbit Polyclonal antibody detecting PARD6A in WB. Suitable for Human, Mouse, Rat, Cow, Horse, Rabbit, Guinea Pig and Dog.

Quick Overview for PARD6A antibody (N-Term) (ABIN2775615)

Target: PARD6A (Par-6 Partitioning Defective 6 Homolog alpha (PARD6A))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Guinea Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARD6A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PARD6A Antibody

Binding Specificity: N-Term

Sequence: MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PARD6A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PARD6A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 345 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PARD6A

Target: PARD6A (Par-6 Partitioning Defective 6 Homolog alpha (PARD6A))

Alternative Name: PARD6A

Background: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40
Protein Interaction Partner: PRKCI, WDR83, PRKCZ, FBXO31, PARD3, UBC, TUBG1, ARHGAP17, VHL, MAP2K5, TJP1, SMURF1, TGFB1, WDR92, PARD6B, PDRG1, RPAP3, MARK4, PIH1D1, SUGT1, YWHAZ, YWHAH, LLGL1, LLGL2, MARK2, CDC42, CRB3, ECT2, PLCB1, RHOQ, PRKCH, RAC1, CDH5, PLCB3, TGFBR1, TCP10, PRKC
Protein Size: 345

Molecular Weight: 37 kDa

Gene ID: 50855

NCBI Accession: NM_001037281, NP_001032358

UniProt: Q3TY70

Pathways: Cell-Cell Junction Organization