PARD6B antibody (N-Term)

Catalog No. ABIN2775630

This Rabbit Polyclonal antibody specifically detects PARD6B in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for PARD6B antibody (N-Term) (ABIN2775630)

Target: PARD6B (Par-6 Partitioning Defective 6 Homolog beta (PARD6B))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARD6B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PARD6B Antibody

Binding Specificity: N-Term

Sequence: SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV GYADIHGDLL

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 77%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against Pard6b. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Pard6b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PARD6B

Target: PARD6B (Par-6 Partitioning Defective 6 Homolog beta (PARD6B))

Alternative Name: Pard6b

Background: Pard6b is a adapter protein involved in asymmetrical cell division and cell polarization processes. It is probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Alias Symbols: AV025615, Par6b
Protein Interaction Partner: Llgl1,
Protein Size: 371

Molecular Weight: 40 kDa

Gene ID: 58220

NCBI Accession: NM_021409, NP_067384

UniProt: Q9JK83

Pathways: Cell-Cell Junction Organization