COLQ antibody (N-Term)

Catalog No. ABIN2775748

The Rabbit Polyclonal anti-COLQ antibody is suitable to detect COLQ in samples from Human, Mouse, Rat, Cow, Horse and Rabbit. It has been validated for WB.

Quick Overview for COLQ antibody (N-Term) (ABIN2775748)

Target: COLQ (AChE Q Subunit (COLQ))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COLQ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COLQ Antibody

Binding Specificity: N-Term

Purpose: COLQ Antibody - N-terminal region

Sequence: LQLFFLSIVS QPTFINSVLP ISAALPSLDQ KKRGGHKACC LLTPPPPPLF

Predicted Reactivity: Cow: 86%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against COLQ. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human COLQ

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8093799

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for COLQ

Target: COLQ (AChE Q Subunit (COLQ))

Alternative Name: COLQ

Background:

Background Information: COLQ encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in COLQ are associated with endplate acetylcholinesterase deficiency.

Gene Name: Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

Alternative Symbols: EAD, CMS5

Protein Name: Acetylcholinesterase collagenic tail peptide

Molecular Weight: 48kDa

Gene ID: 8292

NCBI Accession: NP_005668

UniProt: Q6DK18