TRIM24 antibody (Middle Region)

Catalog No. ABIN2775799

This Rabbit Polyclonal antibody specifically detects TRIM24 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for TRIM24 antibody (Middle Region) (ABIN2775799)

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM24 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIM24 Antibody

Binding Specificity: Middle Region

Sequence: QQPSISHQQP PPRLINFQNH SPKPNGPVLP PHPQQLRYPP NQNIPRQAIK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 82%

Characteristics: This is a rabbit polyclonal antibody against TRIM24. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIM24

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1050 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Alternative Name: TRIM24

Background: The exact function of TRIM24 remains unknown. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Protein Interaction Partner: UBC, SUMO2, SUMO3, TRIM33, TP53, SUMO1, RNF2, RNF181, RNF141, ESR2, BRCA1, SF3B1, SF3B2, SNRPA, NONO, CDK12, NCOA1, TRIM8, NR3C2, ESR1, HIST1H3E, HIST2H4B, HIST4H4, HIST1H3F, HIST2H4A, HIST1H4L, HIST1H4E, HIST1H4B, HIST1H4H, HIST1H4C, HIST1H4J, HIST1H4K,
Protein Size: 1050

Molecular Weight: 117 kDa

Gene ID: 8805

NCBI Accession: NM_015905, NP_056989

UniProt: O15164