SUV420H1 antibody (Middle Region)

Catalog No. ABIN2775877

Cited in 3+ publications. The Rabbit Polyclonal anti-SUV420H1 antibody (ABIN2775877) specifically detects SUV420H1 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig and Horse samples.

Quick Overview for SUV420H1 antibody (Middle Region) (ABIN2775877)

Target: SUV420H1 (Suppressor of Variegation 4-20 Homolog 1 (SUV420H1))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV420H1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SUV420H1 Antibody

Binding Specificity: Middle Region

Purpose: KMT5B Antibody - middle region

Sequence: NNGFNSGSGS SSTKLKIQLK RDEENRGSYT EGLHENGVCC SDPLSLLESR

Predicted Reactivity: Dog: 86%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 91%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SUV420H1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SUV420H1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8113125

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-SUV420H1 antibody (ABIN2775877)

Murata, Kondo, Sugimoto, Kawashima, Saito, Isomura, Kanda, Tsurumi: "Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells." in: Journal of virology, Vol. 86, Issue 9, pp. 4752-61, (2012) (PubMed).

Gatta, Mantovani: "NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations." in: Nucleic acids research, Vol. 36, Issue 20, pp. 6592-607, (2008) (PubMed).

Twells, Metzker, Brown, Cox, Garey, Hammond, Hey, Levy, Nakagawa, Philips, Todd, Hess: "The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13." in: Genomics, Vol. 72, Issue 3, pp. 231-42, (2001) (PubMed).

Target Details for SUV420H1

Target: SUV420H1 (Suppressor of Variegation 4-20 Homolog 1 (SUV420H1))

Alternative Name: KMT5B

Background:

Background Information: This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: lysine methyltransferase 5B

Alternative Symbols: CGI85, MRD51, CGI-85, SUV420H1

Protein Name: histone-lysine N-methyltransferase KMT5B

Molecular Weight: 99 kDa

Gene ID: 51111

UniProt: Q4FZB7