HDAC8 antibody (N-Term)

Catalog No. ABIN2775889

This anti-HDAC8 antibody is a Rabbit Polyclonal antibody detecting HDAC8 in WB. Suitable for Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig and Horse.

Quick Overview for HDAC8 antibody (N-Term) (ABIN2775889)

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC8 Antibody

Binding Specificity: N-Term

Sequence: MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 91%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against HDAC8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HDAC8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 377 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC8

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Alternative Name: HDAC8

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HDACL1, RPD3, HD8, CDA07
Protein Interaction Partner: MDM1, HDAC8, ZSCAN2, CHCHD3, STAG2, SEC16A, CROCC, SMC3, CPNE3, SMC1A, TPM4, TPM3, SVIL, NUP98, MME, ADD3, SMG5, SMG6, HSP90AA1, HSPA4, HIST4H4, HIST3H3, UBC, PRKACA, HIST1H4A, HIST1H3A, ESRRA, ACTA1, RTN1, PPP1CC, CREB1, HIST2H4A, RUNX1T1, CBFA2T3, MDC1,
Protein Size: 377

Molecular Weight: 42 kDa

Gene ID: 55869

NCBI Accession: NM_018486, NP_060956

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process