HDAC8 antibody (C-Term)

Catalog No. ABIN2775890

This Rabbit Polyclonal antibody specifically detects HDAC8 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Pig and Zebrafish (Danio rerio).

Quick Overview for HDAC8 antibody (C-Term) (ABIN2775890)

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC8 Antibody

Binding Specificity: C-Term

Sequence: TGVILGKTLS SEIPDHEFFT AYGPDYVLEI TPSCRPDRNE PHRIQQILNY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against HDAC8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 377 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC8

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Alternative Name: HDAC8

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HDACL1, RPD3, HD8, CDA07
Protein Interaction Partner: MDM1, HDAC8, ZSCAN2, CHCHD3, STAG2, SEC16A, CROCC, SMC3, CPNE3, SMC1A, TPM4, TPM3, SVIL, NUP98, MME, ADD3, SMG5, SMG6, HSP90AA1, HSPA4, HIST4H4, HIST3H3, UBC, PRKACA, HIST1H4A, HIST1H3A, ESRRA, ACTA1, RTN1, PPP1CC, CREB1, HIST2H4A, RUNX1T1, CBFA2T3, MDC1,
Protein Size: 377

Molecular Weight: 42 kDa

Gene ID: 55869

NCBI Accession: NM_018486, NP_060956

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process