DMP1 antibody (C-Term)

Catalog No. ABIN2775903

This Rabbit Polyclonal antibody specifically detects DMP1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Rabbit and Guinea Pig.It has been mentioned in 1 publication

Quick Overview for DMP1 antibody (C-Term) (ABIN2775903)

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-DMP1 Antibody

Binding Specificity: C-Term

Purpose: DMTF1 Antibody - C-terminal region

Sequence: SFNDAHVSKF SDQNSTELMN SVMVRTEEEI SDTDLKQEES PSDLASAYVT

Predicted Reactivity: Dog: 92%, Guinea Pig: 91%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DMTF1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8098132

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-DMP1 antibody (ABIN2775903)

Yang, Kitamura, Wu, Chang, Ling, Kuo: "Tooth Germ-Like Construct Transplantation for Whole-Tooth Regeneration: An In Vivo Study in the Miniature Pig." in: Artificial organs, Vol. 40, Issue 4, pp. E39-50, (2016) (PubMed).

Target Details for DMP1

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Alternative Name: DMTF1

Background:

Background Information: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 35 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: cyclin D binding myb like transcription factor 1

Alternative Symbols: DMP1, DMTF, MRUL, hDMP1

Protein Name: cyclin-D-binding Myb-like transcription factor 1

Molecular Weight: 54kDa

Gene ID: 9988

UniProt: Q9Y222