Forkhead Box K2 antibody (Middle Region)

Catalog No. ABIN2776014

There is 1 publication for this product available. The Rabbit Polyclonal anti-Forkhead Box K2 antibody is suitable to detect Forkhead Box K2 in samples from Human, Mouse, Rat, Rabbit, Horse, Cow, Pig and Dog. It has been validated for WB and IHC.

Quick Overview for Forkhead Box K2 antibody (Middle Region) (ABIN2776014)

Target: Forkhead Box K2 (FOXK2)

Reactivity: Human, Mouse, Rat, Rabbit, Horse, Cow, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Forkhead Box K2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Forkhead Box K2 Antibody

Binding Specificity: Middle Region

Purpose: FOXK2 Antibody - middle region

Sequence: ANTYTVSGQA VVTPAAVLAP PKAEAQENGD HREVKVKVEP IPAIGHATLG

Predicted Reactivity: Cow: 93%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 91%, Pig: 93%, Rabbit: 79%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against FOXK2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FOXK2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8100889

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Forkhead Box K2 antibody (ABIN2776014)

Komorek, Kuppuswamy, Subramanian, Vijayalingam, Lomonosova, Zhao, Mymryk, Schmitt, Chinnadurai: "Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors." in: Journal of virology, Vol. 84, Issue 6, pp. 2719-31, (2010) (PubMed).

Target Details for Forkhead Box K2

Target: Forkhead Box K2 (FOXK2)

Alternative Name: FOXK2

Background:

Background Information: FOXK2 contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. Three alternatively spliced transcript variants encoding distinct isoforms have been described.The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene Name: Forkhead box K2

Alternative Symbols: ILF, ILF1, ILF-1, nGTBP

Protein Name: Forkhead box protein K2

Molecular Weight: 69kDa

Gene ID: 3607

NCBI Accession: NP_004505

UniProt: Q01167