CLCNKB antibody (N-Term)

Catalog No. ABIN2776082

The Rabbit Polyclonal anti-CLCNKB antibody is suitable to detect CLCNKB in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for CLCNKB antibody (N-Term) (ABIN2776082)

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCNKB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CLCNKB Antibody

Binding Specificity: N-Term

Purpose: CLCNKB Antibody - N-terminal region

Sequence: MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CLCNKB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLCNKB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34916-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CLCNKB

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Alternative Name: CLCNKB

Background:

Background Information: Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter Syndrome. CLCNKA and CLCNKB are closely related (94 % sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.

Gene Name: Chloride channel, voltage-sensitive Kb

Alternative Symbols: CLCKB, ClC-K2, ClC-Kb

Protein Name: CLCNKB protein EMBL AAH20873.1

Molecular Weight: 50kDa

Gene ID: 1188

UniProt: Q8WW53