CACNA2D1 antibody (Middle Region)

Catalog No. ABIN2776091

There are 2+ publications for this product available. The Rabbit Polyclonal anti-CACNA2D1 antibody is suitable to detect CACNA2D1 in samples from Human, Rat, Mouse, Rabbit, Dog, Cow, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for CACNA2D1 antibody (Middle Region) (ABIN2776091)

Target: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Reactivity: Human, Rat, Mouse, Rabbit, Dog, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA2D1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CACNA2D1 Antibody

Binding Specificity: Middle Region

Sequence: PKSQEPVTLD FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CACNA2D1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CACNA2D1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1091 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CACNA2D1 antibody (ABIN2776091)

Tétreault, Bourdin, Briot, Segura, Lesage, Fiset, Parent: "Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity." in: The Journal of biological chemistry, Vol. 291, Issue 9, pp. 4826-43, (2016) (PubMed).

Stotz, Barr, McRory, Chen, Jarvis, Zamponi: "Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3793-800, (2004) (PubMed).

Target Details for CACNA2D1

Target: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Alternative Name: CACNA2D1

Background: CACNA2D1 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Alias Symbols: CACNA2, CCHL2A, CACNL2A
Protein Interaction Partner: STT3B, RAB11A, NDUFS4, Cep76,
Protein Size: 1091

Molecular Weight: 120 kDa

Gene ID: 781

NCBI Accession: NM_000722, NP_000713

UniProt: P54289