KCNK3 antibody (C-Term)

Catalog No. ABIN2776142

This Rabbit Polyclonal antibody specifically detects KCNK3 in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow, Guinea Pig, Sheep and Rabbit. It has been mentioned in 2+ publications

Quick Overview for KCNK3 antibody (C-Term) (ABIN2776142)

Target: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Sheep, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNK3 Antibody

Binding Specificity: C-Term

Purpose: KCNK3 Antibody - C-terminal region

Sequence: TCVEQSHSSP GGGGRYSDTP SRRCLCSGAP RSAISSVSTG LHSLSTFRGL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against KCNK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNK3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8108630

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-KCNK3 antibody (ABIN2776142)

Donner, Schullenberg, Geduldig, Hüning, Mersmann, Zacharowski, Kovacevic, Decking, Aller, Schmidt: "Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability." in: Basic research in cardiology, Vol. 106, Issue 1, pp. 75-87, (2010) (PubMed).

Nogueira, Gerry, Mantero, Mariniello, Rainey: "The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas." in: Clinical endocrinology, Vol. 73, Issue 1, pp. 22-9, (2010) (PubMed).

Target Details for KCNK3

Target: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Alternative Name: KCNK3

Background:

Background Information: KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Gene Name: Potassium channel, subfamily K, member 3

Alternative Symbols: OAT1, PPH4, TASK, TASK1, TBAK1, K2p3.1, TASK-1

Protein Name: Potassium channel subfamily K member 3

Molecular Weight: 43kDa

Gene ID: 3777

NCBI Accession: NP_002237

UniProt: O14649