VDAC2 antibody (N-Term)

Catalog No. ABIN2776154

There is 1 publication for this product available. The Rabbit Polyclonal anti-VDAC2 antibody is suitable to detect VDAC2 in samples from Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Sheep. It has been validated for WB and IHC.

Quick Overview for VDAC2 antibody (N-Term) (ABIN2776154)

Target: VDAC2 (Voltage-Dependent Anion Channel 2 (VDAC2))

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VDAC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-VDAC2 Antibody

Binding Specificity: N-Term

Sequence: MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against VDAC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human VDAC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 294 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-VDAC2 antibody (ABIN2776154)

Hrabakova, Kollareddy, Tyleckova, Halada, Hajduch, Gadher, Kovarova: "Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy." in: Journal of proteome research, Vol. 12, Issue 1, pp. 455-69, (2013) (PubMed).

Target Details for VDAC2

Target: VDAC2 (Voltage-Dependent Anion Channel 2 (VDAC2))

Alternative Name: VDAC2

Background: VDAC2 forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Alias Symbols: RP11-375G3.1, FLJ23841, POR
Protein Interaction Partner: MDM2, ADRB2, FBXO6, PARK2, PHKG2, PHB, VCAM1, UBC, ITGA4, FN1, ATF2, env, MDC1, ECT2, ACAA2, TRAP1, ATP6V1F, VDAC3, VDAC1, UBE2L3, UBA52, SSBP1, SCP2, RPN1, MPV17, RPSA, HNRNPU, FLOT2, ELAVL1, DDOST, APP, Htt, ZNF454, SFXN3, THOC6, SUGP1, SEPT11, ZFR, ATP
Protein Size: 294

Molecular Weight: 32 kDa

Gene ID: 7417

NCBI Accession: NM_003375, NP_003366