CLCA2 antibody (C-Term)

Catalog No. ABIN2776187

The Rabbit Polyclonal anti-CLCA2 antibody is suitable to detect CLCA2 in samples from Human, Mouse, Cow, Dog, Horse, Pig, Rabbit and Rat. It has been validated for WB.

Quick Overview for CLCA2 antibody (C-Term) (ABIN2776187)

Target: CLCA2 (Chloride Channel Accessory 2 (CLCA2))

Reactivity: Human, Mouse, Cow, Dog, Horse, Pig, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCA2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CLCA2 Antibody

Binding Specificity: C-Term

Purpose: CLCA2 Antibody - C-terminal region

Sequence: RYFFSFAANG RYSLKVHVNH SPSISTPAHS IPGSHAMYVP GYTANGNIQM

Predicted Reactivity: Cow: 100%, Dog: 85%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 77%, Rabbit: 92%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CLCA2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLCA2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP35195-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CLCA2

Target: CLCA2 (Chloride Channel Accessory 2 (CLCA2))

Alternative Name: CLCA2

Background:

Background Information: The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.

Gene Name: Chloride channel accessory 2

Alternative Symbols: CACC, CACC3, CLCRG2, CaCC-3

Protein Name: Calcium-activated chloride channel regulator 2

Molecular Weight: 104 kDa

Gene ID: 9635

NCBI Accession: NP_006527

UniProt: Q9UQC9