KCNMB3 antibody (Middle Region)

Catalog No. ABIN2776296

The Rabbit Polyclonal anti-KCNMB3 antibody (ABIN2776296) specifically detects KCNMB3 in WB. The antibody is reactive with Human, Rat and Dog samples.

Quick Overview for KCNMB3 antibody (Middle Region) (ABIN2776296)

Target: KCNMB3 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M beta Member 3 (KCNMB3))

Reactivity: Human, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNMB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNMB3 Antibody

Binding Specificity: Middle Region

Sequence: SLTLLGGALI VGMVRLTQHL SLLCEKYSTV VRDEVGGKVP YIEQHQFKLC

Predicted Reactivity: Dog: 91%, Human: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against KCNMB3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNMB3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 277 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KCNMB3

Target: KCNMB3 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M beta Member 3 (KCNMB3))

Alternative Name: KCNMB3

Background: KCNMB3 is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for KCNMB3.MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.
Alias Symbols: KCNMB2, KCNMBL, HBETA3, BKBETA3, SLOBETA3
Protein Size: 277

Molecular Weight: 31 kDa

Gene ID: 27094

NCBI Accession: NM_171828, NP_741979