CATSPER2 antibody (N-Term)

Catalog No. ABIN183176

There is 1 publication for this product available. The Rabbit Polyclonal anti-CATSPER2 antibody is suitable to detect CATSPER2 in samples from Human, Cow, Rabbit, Horse and Pig. It has been validated for WB and IHC.

Quick Overview for CATSPER2 antibody (N-Term) (ABIN183176)

Target: CATSPER2 (Cation Channel, Sperm Associated 2 (CATSPER2))

Reactivity: Human, Cow, Rabbit, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CATSPER2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CATSPER2 Antibody

Binding Specificity: N-Term

Purpose: CATSPER2 Antibody - N-terminal region

Sequence: HLQGLSQAVP RHTIRELLDP SRQKKLVLGD QHQLVRFSIK PQRIEQISHA

Predicted Reactivity: Cow: 85%, Horse: 92%, Human: 100%, Pig: 92%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against CATSPER2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CATSPER2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8096410

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CATSPER2 antibody (ABIN183176)

Kawano, Araki, Yoshida, Hibino, Ohnami, Makino, Kanai, Hasuwa, Yoshida, Miyado, Umezawa: "Seminal vesicle protein SVS2 is required for sperm survival in the uterus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 11, pp. 4145-50, (2014) (PubMed).

Target Details for CATSPER2

Target: CATSPER2 (Cation Channel, Sperm Associated 2 (CATSPER2))

Alternative Name: CATSPER2

Background:

Background Information: Calcium ions play a primary role in the regulation of sperm motility. Anti-CATSPER2 belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. A second, closely linked copy of this gene has been identified. Although multiple transcript variants encoding protein isoforms have been characterized, they seem to be only transcribed from this gene. Additional splice variants have been described but their full-length nature has not been determined.

Gene Name: Cation channel, sperm associated 2

Protein Name: Cation channel sperm-associated protein 2

Molecular Weight: 46kDa

Gene ID: 117155

NCBI Accession: NP_742094

UniProt: Q96P54