EXOSC6 antibody (N-Term)

Catalog No. ABIN2776613

This Rabbit Polyclonal antibody specifically detects EXOSC6 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig and Zebrafish (Danio rerio).

Quick Overview for EXOSC6 antibody (N-Term) (ABIN2776613)

Target: EXOSC6 (Exosome Component 6 (EXOSC6))

Reactivity: Human, Mouse, Rat, Cow, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EXOSC6 Antibody

Binding Specificity: N-Term

Purpose: EXOSC6 Antibody - N-terminal region

Sequence: LYAADEEEAP GTRDPTRLRP VYARAGLLSQ AKGSAYLEAG GTKVLCAVSG

Predicted Reactivity: Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against EXOSC6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8100083

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for EXOSC6

Target: EXOSC6 (Exosome Component 6 (EXOSC6))

Alternative Name: EXOSC6

Background:

Background Information: EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Gene Name: Exosome component 6

Alternative Symbols: p11, EAP4, MTR3, Mtr3p, hMtr3p

Protein Name: Exosome complex component MTR3

Molecular Weight: 30kDa

Gene ID: 118460

NCBI Accession: NP_478126

UniProt: Q5RKV6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response