WDR4 antibody (N-Term)

Catalog No. ABIN2776746

This Rabbit Polyclonal antibody specifically detects WDR4 in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Cow, Rabbit, Dog and Guinea Pig.

Quick Overview for WDR4 antibody (N-Term) (ABIN2776746)

Target: WDR4 (WD Repeat Domain 4 (WDR4))

Reactivity: Human, Mouse, Rat, Horse, Cow, Rabbit, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WDR4 Antibody

Binding Specificity: N-Term

Purpose: WDR4 Antibody - N-terminal region

Sequence: FIYDCSAAEK KSQENKGEDA PLDQGSGAIL ASTFSKSGSY FALTDDSKRL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against WDR4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human WDR4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41320-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for WDR4

Target: WDR4 (WD Repeat Domain 4 (WDR4))

Alternative Name: WDR4

Background:

Targeted Subunit: WDR4

Background Information: WDR4 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: WD repeat domain 4

Alternative Symbols: hWH, Wuho, MIGSB, TRM82, GAMOS6, TRMT82

Protein Name: tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

Molecular Weight: 45kDa

Gene ID: 10785

NCBI Accession: NP_061139

UniProt: P57081