ELAC2 antibody (C-Term)

Catalog No. ABIN2776757

This Rabbit Polyclonal antibody specifically detects ELAC2 in WB. It exhibits reactivity toward Human, Mouse, Rat and Dog.

Quick Overview for ELAC2 antibody (C-Term) (ABIN2776757)

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELAC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ELAC2 Antibody

Binding Specificity: C-Term

Purpose: ELAC2 Antibody - C-terminal region

Sequence: ITCNPEEFIV EALQLPNFQQ SVQEYRRSAQ DGPAPAEKRS QYPEIIFLGT

Predicted Reactivity: Dog: 100%, Human: 100%, Mouse: 83%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against ELAC2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ELAC2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41346-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ELAC2

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Alternative Name: ELAC2

Background:

Background Information: The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: elaC homolog 2 (E. coli)

Alternative Symbols: ELC2, HPC2, COXPD17

Protein Name: Zinc phosphodiesterase ELAC protein 2

Molecular Weight: 55kDa

Gene ID: 60528

UniProt: Q9BQ52