MSH6 antibody (N-Term)

Catalog No. ABIN2776759

There is 1 publication for this product available. The Rabbit Polyclonal anti-MSH6 antibody is suitable to detect MSH6 in samples from Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse and Rabbit. It has been validated for WB and IHC.

Quick Overview for MSH6 antibody (N-Term) (ABIN2776759)

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MSH6 Antibody

Binding Specificity: N-Term

Sequence: ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MSH6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MSH6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1360 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MSH6 antibody (ABIN2776759)

Wedrén, Lovmar, Humphreys, Magnusson, Melhus, Syvänen, Kindmark, Landegren, Fermér, Stiger, Persson, Baron, Weiderpass: "Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." in: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).

Target Details for MSH6

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Alternative Name: MSH6

Background: This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide bind
Alias Symbols: GTBP, HNPCC5, HSAP
Protein Interaction Partner: BRCA1, UBC, SUMO2, PCNA, POLK, SAMHD1, GANAB, HYOU1, SUPT5H, XRCC6, ATP6V1B2, UBD, HDAC11, MSH2, CSNK2A1, SUPT16H, MSH3, MLH1, PMS2, RAD9A, RAD1, MUTYH, HUS1, SLX4, CUL3, NEDD8, FBXO25, SIRT7, XRCC5, PRKDC, BLM, TP53, RAD51, PMS1, SMARCAD1, CHAF1A, DTL, S
Protein Size: 1360

Molecular Weight: 153 kDa

Gene ID: 2956

NCBI Accession: NM_000179, NP_000170

UniProt: P52701

Pathways: DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response