MSH6 antibody (N-Term)

Catalog No. ABIN2776759

The Rabbit Polyclonal anti-MSH6 antibody has been validated for WB and IHC. It is suitable to detect MSH6 in samples from Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse and Rabbit. There is 1 publication available.

Quick Overview for MSH6 antibody (N-Term) (ABIN2776759)

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MSH6 Antibody

Binding Specificity: N-Term

Sequence: ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MSH6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MSH6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1360 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MSH6 antibody (ABIN2776759)

Wedrén, Lovmar, Humphreys, Magnusson, Melhus, Syvänen, Kindmark, Landegren, Fermér, Stiger, Persson, Baron, Weiderpass: "Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." in: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).

Target Details for MSH6

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Alternative Name: MSH6

Background: This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide bind
Alias Symbols: GTBP, HNPCC5, HSAP
Protein Interaction Partner: BRCA1, UBC, SUMO2, PCNA, POLK, SAMHD1, GANAB, HYOU1, SUPT5H, XRCC6, ATP6V1B2, UBD, HDAC11, MSH2, CSNK2A1, SUPT16H, MSH3, MLH1, PMS2, RAD9A, RAD1, MUTYH, HUS1, SLX4, CUL3, NEDD8, FBXO25, SIRT7, XRCC5, PRKDC, BLM, TP53, RAD51, PMS1, SMARCAD1, CHAF1A, DTL, S
Protein Size: 1360

Molecular Weight: 153 kDa

Gene ID: 2956

NCBI Accession: NM_000179, NP_000170

UniProt: P52701

Pathways: DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response