ASS1 antibody (C-Term)

Catalog No. ABIN2776769

Cited in 1 publication. The Rabbit Polyclonal anti-ASS1 antibody (ABIN2776769) specifically detects ASS1 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Goat and Rabbit samples.

Quick Overview for ASS1 antibody (C-Term) (ABIN2776769)

Target: ASS1 (Argininosuccinate Synthase 1 (ASS1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Goat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ASS1 Antibody

Binding Specificity: C-Term

Purpose: ASS Antibody - C-terminal region

Sequence: SVLKGQVYIL GRESPLSLYN EELVSMNVQG DYEPTDATGF ININSLRLKE

Predicted Reactivity: Cow: 93%, Dog: 93%, Goat: 92%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ASS. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ASS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41367-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ASS1 antibody (ABIN2776769)

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Target Details for ASS1

Target: ASS1 (Argininosuccinate Synthase 1 (ASS1))

Background:

Background Information: ASS catalyzes the penultimate step of the arginine biosynthetic pathway.The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: Argininosuccinate synthase 1

Alternative Symbols: ASS, CTLN1

Protein Name: Argininosuccinate synthase

Molecular Weight: 47 kDa

Gene ID: 445

NCBI Accession: NP_446464

UniProt: P00966

Pathways: Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin