DDC antibody (N-Term)

Catalog No. ABIN2776802

There is 1 publication for this product available. The Rabbit Polyclonal anti-DDC antibody is suitable to detect DDC in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse and Zebrafish (Danio rerio). It has been validated for WB and IHC.

Quick Overview for DDC antibody (N-Term) (ABIN2776802)

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-DDC Antibody

Binding Specificity: N-Term

Purpose: DDC Antibody - N-terminal region

Sequence: EFRRRGKEMV DYVANYMEGI EGRQVYPDVE PGYLRPLIPA AAPQEPDTFE

Predicted Reactivity: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 92%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against DDC. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DDC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8099153

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-DDC antibody (ABIN2776802)

Shimohata, Ishihara, Hattori, Miyamoto, Morishita, Ornthanalai, Raveau, Ebrahim, Amano, Yamada, Sago, Akiba, Mataga, Murphy, Miyakawa, Yamakawa: "Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism." in: Experimental neurology, Vol. 293, pp. 1-12, (2017) (PubMed).

Target Details for DDC

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Alternative Name: DDC

Background:

Background Information: DDC catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Gene Name: Dopa decarboxylase (aromatic L-amino acid decarboxylase)

Alternative Symbols: AADC

Protein Name: Aromatic-L-amino-acid decarboxylase

Molecular Weight: 53kDa

Gene ID: 1644

NCBI Accession: NP_000781

UniProt: P20711

Pathways: Dopaminergic Neurogenesis