Desmin antibody (N-Term)

Catalog No. ABIN2776842

The Rabbit Polyclonal anti-Desmin antibody is suitable to detect Desmin in samples from Human, Rat, Mouse, Dog, Cow, Rabbit, Horse and Guinea Pig. It has been validated for WB.

Quick Overview for Desmin antibody (N-Term) (ABIN2776842)

Target: Desmin (DES)

Reactivity: Human, Rat, Mouse, Dog, Cow, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Desmin Antibody

Binding Specificity: N-Term

Sequence: PLSSPVFPRA GFGSKGSSSS VTSRVYQVSR TSGGAGGLGS LRASRLGTTR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against DES. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DES

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 470 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: DES

Background: DES is a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in its gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Alias Symbols: CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793
Protein Interaction Partner: PPP1R18, UBE2I, EHHADH, TRIM63, TRIM55, UBC, YWHAQ, MAPKAPK2, CAPN1, MLH1, AURKB, HADHB, MYL6, JUP, HSP90AA5P, HNRNPUL1, CCT7, SNRNP70, RPL29, RPL17, UBD, CRYAB, SHBG, SP1, ITSN1, NEB, PLEKHA5, SYNC, TRIM7, SYNM, ROCK1, PKD1, SPTAN1, S100B, S100A1, DSP,
Protein Size: 470

Molecular Weight: 52 kDa

Gene ID: 1674

NCBI Accession: NM_001927, NP_001918

UniProt: P17661