ALAS2 antibody (N-Term)

Catalog No. ABIN2776923

This Rabbit Polyclonal antibody specifically detects ALAS2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Dog, Horse and Pigand has been mentioned in 1 publication.

Quick Overview for ALAS2 antibody (N-Term) (ABIN2776923)

Target: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALAS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALAS2 Antibody

Binding Specificity: N-Term

Sequence: CPILATQGPN CSQIHLKATK AGGDSPSWAK GHCPFMLSEL QDGKSKIVQK

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ALAS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ALAS2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 550 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ALAS2 antibody (ABIN2776923)

Chien, Chang, Lee, Su, Wu: "Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cells." in: Journal of cellular biochemistry, Vol. 99, Issue 1, pp. 292-304, (2006) (PubMed).

Target Details for ALAS2

Target: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Alternative Name: ALAS2

Background: ALAS2 specifies an erythroid-specific mitochondrially located enzyme. The protein catalyzes the first step in the heme biosynthetic pathway. Defects in its gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: ANH1, ASB, XLSA, ALASE, XLDPP, XLEPP, ALAS-E
Protein Interaction Partner: BANP, GRB2, SUCLA2, RABGGTB,
Protein Size: 550

Molecular Weight: 60 kDa

Gene ID: 212

NCBI Accession: NM_001037967, NP_001033056

UniProt: P22557

Pathways: Transition Metal Ion Homeostasis