GAMT antibody (N-Term)

Catalog No. ABIN2776937

The Rabbit Polyclonal anti-GAMT antibody (ABIN2776937) specifically detects GAMT in WB. The antibody is reactive with Human, Rat, Mouse, Guinea Pig, Cow and Pig samples.

Quick Overview for GAMT antibody (N-Term) (ABIN2776937)

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Reactivity: Human, Rat, Mouse, Guinea Pig, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAMT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GAMT Antibody

Binding Specificity: N-Term

Purpose: GAMT Antibody - N-terminal region

Sequence: MSAPSATPIF APGENCSPAW GAAPAAYDAA DTHLRILGKP VMERWETPYM

Predicted Reactivity: Cow: 92%, Guinea Pig: 85%, Human: 100%, Mouse: 92%, Pig: 92%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against GAMT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GAMT

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8102022

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GAMT

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Alternative Name: GAMT

Background:

Background Information: GAMT is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in its gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals.The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene.

Gene Name: Guanidinoacetate N-methyltransferase

Alternative Symbols: PIG2, CCDS2, TP53I2, HEL-S-20

Protein Name: Guanidinoacetate N-methyltransferase

Molecular Weight: 26kDa

Gene ID: 2593

NCBI Accession: NP_000147

UniProt: Q14353