LSS antibody (N-Term)

Catalog No. ABIN2777020

The Rabbit Polyclonal anti-LSS antibody is suitable to detect LSS in samples from Human, Rat, Mouse, Cow, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for LSS antibody (N-Term) (ABIN2777020)

Target: LSS (Lanosterol Synthase (2,3-Oxidosqualene-Lanosterol Cyclase) (LSS))

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LSS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LSS Antibody

Binding Specificity: N-Term

Purpose: LSS Antibody - N-terminal region

Sequence: TEGTCLRRRG GPYKTEPATD LGRWRLNCER GRQTWTYLQD ERAGREQTGL

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against LSS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LSS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104161

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LSS

Target: LSS (Lanosterol Synthase (2,3-Oxidosqualene-Lanosterol Cyclase) (LSS))

Alternative Name: LSS

Background:

Background Information: LSS catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. It is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Two transcript variants encoding the same protein have been found for this gene.The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

Alternative Symbols: OSC, APMR4, HYPT14, CTRCT44

Protein Name: Lanosterol synthase

Molecular Weight: 83 kDa

Gene ID: 4047

NCBI Accession: NP_002331

UniProt: P48449