SLC6A2 antibody (Middle Region)

Catalog No. ABIN2777051

There are 2+ publications for this product available. The Rabbit Polyclonal anti-SLC6A2 antibody is suitable to detect SLC6A2 in samples from Human, Rat, Mouse, Cow, Dog, Horse, Rabbit and Guinea Pig. It has been validated for WB.

Quick Overview for SLC6A2 antibody (Middle Region) (ABIN2777051)

Target: SLC6A2 (Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2))

Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SLC6A2 Antibody

Binding Specificity: Middle Region

Purpose: SLC6A2 Antibody - middle region

Sequence: STLSGSTFWA VVFFVMLLAL GLDSSMGGME AVITGLADDF QVLKRHRKLF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SLC6A2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SLC6A2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41893-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-SLC6A2 antibody (ABIN2777051)

Bayles, Harikrishnan, Lambert, Baker, Agrotis, Guo, Jowett, Esler, Lambert, El-Osta: "Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 32, Issue 8, pp. 1910-6, (2012) (PubMed).

Suzuki, Matsumoto, Oshino, Kamata, Goto, Otani: "Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females." in: Neuroscience letters, Vol. 439, Issue 1, pp. 52-5, (2008) (PubMed).

Target Details for SLC6A2

Target: SLC6A2 (Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2))

Alternative Name: SLC6A2

Background:

Background Information: The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis.The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis (Kim et al., 2006 [PubMed 17146058]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

Alternative Symbols: NET, NAT1, NET1, SLC6A5

Protein Name: Sodium-dependent noradrenaline transporter

Molecular Weight: 69kDa

Gene ID: 6530

NCBI Accession: NP_001034

UniProt: P23975