LEFTY2 antibody (N-Term)

Catalog No. ABIN310282

This Rabbit Polyclonal antibody specifically detects LEFTY2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Pig, Cow and Horse.

Quick Overview for LEFTY2 antibody (N-Term) (ABIN310282)

Target: LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEFTY2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LEFTY2 Antibody

Binding Specificity: N-Term

Purpose: LEFTY2 Antibody - N-terminal region

Sequence: MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK

Predicted Reactivity: Cow: 79%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 86%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against LEFTY2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LEFTY2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104203

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LEFTY2

Target: LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))

Alternative Name: LEFTY2

Background:

Background Information: LEFTY2 is a member of the TGF-beta family of proteins. The protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in its gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of its gene in the endometrium.This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Gene Name: Left-right determination factor 2

Alternative Symbols: EBAF, LEFTA, TGFB4, LEFTYA

Protein Name: Left-right determination factor 2

Molecular Weight: 40kDa

Gene ID: 7044

NCBI Accession: NP_003231

UniProt: O00292