UPP1 antibody (N-Term)

Catalog No. ABIN405444

Cited in 1 publication. The Rabbit Polyclonal anti-UPP1 antibody (ABIN405444) specifically detects UPP1 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio) and Guinea Pig samples.

Quick Overview for UPP1 antibody (N-Term) (ABIN405444)

Target: UPP1 (Uridine Phosphorylase 1 (UPP1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UPP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UPP1 Antibody

Binding Specificity: N-Term

Purpose: UPP1 Antibody - N-terminal region

Sequence: AATGANAEKA ESHNDCPVRL LNPNIAKMKE DILYHFNLTT SRHNFPALFG

Predicted Reactivity: Cow: 85%, Guinea Pig: 75%, Horse: 83%, Human: 100%, Mouse: 85%, Rat: 85%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against UPP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UPP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42125-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-UPP1 antibody (ABIN405444)

Temmink, de Bruin, Laan, Turksma, Cricca, Masterson, Noordhuis, Peters: "The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells." in: The international journal of biochemistry & cell biology, Vol. 38, Issue 10, pp. 1759-65, (2006) (PubMed).

Target Details for UPP1

Target: UPP1 (Uridine Phosphorylase 1 (UPP1))

Alternative Name: UPP1

Background:

Background Information: UPP1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Gene Name: Uridine phosphorylase 1

Alternative Symbols: UP, UPP, UPASE, UDRPASE

Protein Name: Uridine phosphorylase 1

Molecular Weight: 34kDa

Gene ID: 7378

NCBI Accession: NP_003355

UniProt: Q16831

Pathways: Ribonucleoside Biosynthetic Process