IRF8 antibody (C-Term)

Catalog No. ABIN2777225

This Rabbit Polyclonal antibody specifically detects IRF8 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit and Pig.It has been mentioned in 1 publication

Quick Overview for IRF8 antibody (C-Term) (ABIN2777225)

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF8 Antibody

Binding Specificity: C-Term

Purpose: IRF8 Antibody - C-terminal region

Sequence: QLAEEAGKSC GAGSVMQAPE EPPPDQVFRM FPDICASHQR SFFRENQQIT

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against IRF8. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31199-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRF8 antibody (ABIN2777225)

Ye, Wang, Wang, Wang, Song, Hou, Zhou, Li, Ho: "CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes." in: Hepatology (Baltimore, Md.), Vol. 49, Issue 3, pp. 753-62, (2009) (PubMed).

Target Details for IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Alternative Name: IRF8

Background:

Background Information: Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-. and IFN-.. IRF family proteins also control expression of IFN-. and IFN-.-regulated genes that are induced by viral infection.

Gene Name: Interferon regulatory factor 8

Alternative Symbols: ICSBP, IRF-8, ICSBP1, IMD32A, IMD32B, H-ICSBP

Protein Name: Interferon regulatory factor 8

Molecular Weight: 48kDa

Gene ID: 3394

NCBI Accession: NP_002154

UniProt: Q02556

Pathways: Cellular Response to Molecule of Bacterial Origin