DR1 antibody (Middle Region)

Catalog No. ABIN2777245

The Rabbit Polyclonal anti-DR1 antibody is suitable to detect DR1 in samples from Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Horse, Rabbit, Pig and Guinea Pig. It has been validated for WB.

Quick Overview for DR1 antibody (Middle Region) (ABIN2777245)

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Horse, Rabbit, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DR1 Antibody

Binding Specificity: Middle Region

Purpose: Dr1 Antibody - middle region

Sequence: KKTISPEHVI QALESLGFGS YISEVKEVLQ ECKTVALKRR KASSRLENLG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Dr1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31272-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DR1

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Alternative Name: Dr1

Background:

Background Information: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Dr1 can bind to DNA on its own. It is a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Name: Down-regulator of transcription 1

Alternative Symbols: Dr, NC, NC2, Dr1l, NC2be, NC2beta, 1700121L09Rik

Protein Name: Protein Dr1

Molecular Weight: 19kDa

Gene ID: 13486

NCBI Accession: NP_080382

UniProt: Q91WV0