TCEB2 antibody (Middle Region)

Catalog No. ABIN2777254

The Rabbit Polyclonal anti-TCEB2 antibody (ABIN2777254) specifically detects TCEB2 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Goat, Pig, Rabbit, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for TCEB2 antibody (Middle Region) (ABIN2777254)

Target: TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Pig, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCEB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TCEB2 Antibody

Binding Specificity: Middle Region

Sequence: TARPQAPATV GLAFRADDTF EALCIEPFSS PPELPDVMKP QDSGSSANEQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against TCEB2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TCEB2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 118 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TCEB2

Target: TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2))

Alternative Name: TCEB2

Background: TCEB2 is the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: SIII, ELOB
Protein Interaction Partner: vif, TCEB1, SOCS4, CUL5, UBC, PRAME, VHL, ASB18, ASB12, ASB14, ASB15, ASB9, ASB8, ASB7, ASB6, ASB5, ASB10, ASB17, ASB16, ASB13, ASB1, ASB3, LRRC47, LARS, EPRS, CDC42, CUL2, ASB2, Zswim8, CSNK1E, NOS2, NEDD8, HIF1A, CFTR, FEM1B, SOCS3, EPAS1, Lrrc41, Wsb1,
Protein Size: 118

Molecular Weight: 13 kDa

Gene ID: 6923

NCBI Accession: NM_007108, NP_009039

UniProt: Q15370

Pathways: SARS-CoV-2 Protein Interactome