HOXA5 antibody (Middle Region)

Catalog No. ABIN2777305

This anti-HOXA5 antibody is a Rabbit Polyclonal antibody detecting HOXA5 in WB and IHC. Suitable for Human, Rat, Mouse, Pig, Rabbit, Cow, Dog and Horse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for HOXA5 antibody (Middle Region) (ABIN2777305)

Target: HOXA5 (Homeobox A5 (HOXA5))

Reactivity: Human, Rat, Mouse, Pig, Rabbit, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXA5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HOXA5 Antibody

Binding Specificity: Middle Region

Sequence: VGTASGAEED APASSEQASA QSEPSPAPPA QPQIYPWMRK LHISHDNIGG

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HOXA5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HOXA5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 270 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HOXA5 antibody (ABIN2777305)

Heshmati, Kharazi, Türköz, Chang, Kamali Dolatabadi, Boström, Krstic, Boukoura, Wagner, Kadri, Månsson, Altun, Qian, Walfridsson: "The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation." in: Scientific reports, Vol. 8, Issue 1, pp. 11202, (2019) (PubMed).

Boucherat, Montaron, Bérubé-Simard, Aubin, Philippidou, Wellik, Dasen, Jeannotte: "Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 304, Issue 12, pp. L817-30, (2013) (PubMed).

Target Details for HOXA5

Target: HOXA5 (Homeobox A5 (HOXA5))

Alternative Name: HOXA5

Background: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
Alias Symbols: HOX1, HOX1.3, HOX1C, MGC9376
Protein Interaction Partner: PRMT6, TWIST1, UBC, ELAVL1, SOX2, ZNF408, GTF2A1L, SMAD1, DDIT3, PBX1, MEIS1, FOXA2, CDX4, FOXO1,
Protein Size: 270

Molecular Weight: 29 kDa

Gene ID: 3202

NCBI Accession: NM_019102, NP_061975

UniProt: Q6FG31