GTF2I antibody (N-Term)

Catalog No. ABIN2777491

This Rabbit Polyclonal antibody specifically detects GTF2I in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig and Rabbit.

Quick Overview for GTF2I antibody (N-Term) (ABIN2777491)

Target: GTF2I (General Transcription Factor III (GTF2I))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2I antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GTF2I Antibody

Binding Specificity: N-Term

Sequence: ILSPGGSCGP IKVKTEPTED SGISLEMAAV TVKEESEDPD YYQYNIQGSH

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GTF2I. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GTF2I

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 978 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GTF2I

Target: GTF2I (General Transcription Factor III (GTF2I))

Alternative Name: GTF2I

Background: GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.
Alias Symbols: WBS, DIWS, SPIN, IB291, BAP135, BTKAP1, TFII-I, WBSCR6, GTFII-I
Protein Interaction Partner: TP53, ZMYM3, PIAS2, TUBG1, TRAF6, SUMO2, SUMO3, AP2B1, DPY30, GCC1, MTUS2, MDM2, UBC, SUMO1, RPA3, RPA2, RPA1, EED, RNF2, SUZ12, CTPS2, WARS, RPL28, RAD23B, PRPS2, PRKDC, NUCB1, METTL1, ADSL, FBXO6, UBD, CBX2, TAB2, AP4S1, CBX4, MAPK12, C4BPA, MAP3K3, SLU
Protein Size: 978

Molecular Weight: 110 kDa

Gene ID: 2969

NCBI Accession: NM_033000, NP_127493

UniProt: Q75M86