AKAP8 antibody (Middle Region)

Catalog No. ABIN2777567

The Rabbit Polyclonal anti-AKAP8 antibody has been validated for WB. It is suitable to detect AKAP8 in samples from Human, Cow, Dog, Horse, Pig and Rabbit.

Quick Overview for AKAP8 antibody (Middle Region) (ABIN2777567)

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Reactivity: Human, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AKAP8 Antibody

Binding Specificity: Middle Region

Sequence: YLKGEDPFTS ETVDPEMEGD DNLGGEDKKE TPEEVAADVL AEVITAAVRA

Predicted Reactivity: Cow: 85%, Dog: 85%, Horse: 92%, Human: 100%, Pig: 92%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against AKAP8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AKAP8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 692 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AKAP8

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Alternative Name: AKAP8

Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP8 is a member of the AKAP family. It is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AKAP95, DKFZp586B1222, AKAP-8, AKAP 95, AKAP-95
Protein Interaction Partner: SUMO2, UBC, RPA3, RPA2, RPA1, BMI1, RNF2, EZH2, HIPK4, HDAC11, CSNK2A1, MYC, ESR1, BARD1, LRRK2, CAND1, COPS5, CUL3, HNRNPA1, ELAVL1, Mis12, Aurkb, TADA2A, CASP3, DDX5, PRKAR2A, CCND1, RELA, CCND3, CCND2, MCM2, AMY1C, AMY1A,
Protein Size: 692

Molecular Weight: 76 kDa

Gene ID: 10270

NCBI Accession: NM_005858, NP_005849

UniProt: O43823

Pathways: SARS-CoV-2 Protein Interactome