HES6 antibody (Middle Region)

Catalog No. ABIN2777652

This Rabbit Polyclonal antibody specifically detects HES6 in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for HES6 antibody (Middle Region) (ABIN2777652)

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HES6 Antibody

Binding Specificity: Middle Region

Sequence: LLAGTEVQAK LENAEVLELT VRRVQGALRG RAREREQLQA EASERFAAGY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 75%, Human: 100%, Mouse: 100%, Rabbit: 75%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against Hes6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Hes6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 224 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HES6

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Alternative Name: Hes6

Background: Hes6 does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Hes6 also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. It promotes cell differentiation.
Alias Symbols: AI326893, bHLHb41
Protein Interaction Partner: Tle1, Tef, Mycn, Ssbp3, Hes1,
Protein Size: 224

Molecular Weight: 24 kDa

Gene ID: 55927

NCBI Accession: NM_019479, NP_062352

UniProt: Q9JHE6