SUFUH antibody (Middle Region)

Catalog No. ABIN2777710

This Rabbit Polyclonal antibody specifically detects SUFUH in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Cow.

Quick Overview for SUFUH antibody (Middle Region) (ABIN2777710)

Target: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUFUH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SUFUH Antibody

Binding Specificity: Middle Region

Sequence: NGQGILELLR TVPIAGGPWL ITDMRRGETI FEIDPHLQER VDKGIETDGS

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SUFU. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SUFU

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 484 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SUFUH

Target: SUFUH (Suppressor of Fused Homolog (SUFUH))

Alternative Name: SUFU

Background: SUFU is a component of the Sonic hedgehog (SHH, MIM 600725)/Patched (PTCH, MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes. SUFU encodes a component of the sonic hedgehog (SHH, MIM 600725)/patched (PTCH, MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945, BCNS, MIM 109400, and GCPS, MIM 175700).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PRO1280, SUFUH, SUFUXL
Protein Interaction Partner: ZNF747, FBXL17, GLIS3, UBC, GLI1, HDX, SAP18, RCN3, PIAS1, PEX26, ZNF764, STK36, ZNF446, QPRT, SETDB1, MID1IP1, RNF19A, SUFU, ZNF219, ZNF263, BTRC, LAMTOR3, NCOA3, HMGA1, GLI3, GLI2, HNRNPA1, LGALS3, RBPJ,
Protein Size: 484

Molecular Weight: 54 kDa

Gene ID: 51684

NCBI Accession: NM_016169, NP_057253

UniProt: Q9UMX1

Pathways: Hedgehog Signaling, Tube Formation, Maintenance of Protein Location