POLE3 antibody (N-Term)

Catalog No. ABIN2777723

This Rabbit Polyclonal antibody specifically detects POLE3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Dog, Zebrafish (Danio rerio), Horse and Rabbit.

Quick Overview for POLE3 antibody (N-Term) (ABIN2777723)

Target: POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Zebrafish (Danio rerio), Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLE3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-POLE3 Antibody

Binding Specificity: N-Term

Sequence: MAERPEDLNL PNAVITRIIK EALPDGVNIS KEARSAISRA ASVFVLYATS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against POLE3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human POLE3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 147 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for POLE3

Target: POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))

Alternative Name: POLE3

Background: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
Alias Symbols: p17, YBL1, CHRAC17, CHARAC17
Protein Interaction Partner: CHRAC1, DRAP1, DR1, UBC, NANS, ANXA6, gag-pol, POLE4, CPSF2, POLE, APP, YEATS2, POLE2, Cebpb, SUMO2, XRCC5, BAZ1A, SMARCA5, RAD17,
Protein Size: 147

Molecular Weight: 17 kDa

Gene ID: 54107

NCBI Accession: NM_017443, NP_059139

UniProt: Q9NRF9

Pathways: DNA Damage Repair