MTA1 antibody (N-Term)

Catalog No. ABIN2777793

The Rabbit Polyclonal anti-MTA1 antibody is suitable to detect MTA1 in samples from Human, Mouse, Rat, Dog, Horse, Rabbit and Cow. It has been validated for WB.

Quick Overview for MTA1 antibody (N-Term) (ABIN2777793)

Target: MTA1 (Metastasis Associated 1 (MTA1))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MTA1 Antibody

Binding Specificity: N-Term

Purpose: MTA1 Antibody - N-terminal region

Sequence: TLIMLADKHA KEIEEESETT VEADLTDKQK HQLKHRELFL SRQYESLPAT

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MTA3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human MTA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33184-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MTA1

Target: MTA1 (Metastasis Associated 1 (MTA1))

Alternative Name: MTA1

Background:

Background Information: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: metastasis associated 1

Protein Name: metastasis-associated protein MTA1

Molecular Weight: 43kDa

Gene ID: 9112

NCBI Accession: NP_001190187

UniProt: Q13330

Pathways: Chromatin Binding