SHOX2 antibody (N-Term)

Catalog No. ABIN2777839

The Rabbit Polyclonal anti-SHOX2 antibody (ABIN2777839) specifically detects SHOX2 in WB. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for SHOX2 antibody (N-Term) (ABIN2777839)

Target: SHOX2 (Short Stature Homeobox 2 (SHOX2))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHOX2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SHOX2 Antibody

Binding Specificity: N-Term

Purpose: SHOX2 Antibody - N-terminal region

Sequence: EELTAFVSKS FDQKVKEKKE AITYREVLES GPLRGAKEPT GCTEAGRDDR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SHOX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SHOX2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33285-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SHOX2

Target: SHOX2 (Short Stature Homeobox 2 (SHOX2))

Alternative Name: SHOX2

Background:

Background Information: SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

Gene Name: Short stature homeobox 2

Alternative Symbols: OG12, SHOT, OG12X

Protein Name: Short stature homeobox protein 2

Molecular Weight: 35 kDa

Gene ID: 6474

NCBI Accession: NP_006875

UniProt: O60902

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development