ATXN7 antibody (Middle Region)

Catalog No. ABIN2777891

This Rabbit Polyclonal antibody specifically detects ATXN7 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Cow and Pigand has been mentioned in 1 publication.

Quick Overview for ATXN7 antibody (Middle Region) (ABIN2777891)

Target: ATXN7 (Ataxin 7 (ATXN7))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATXN7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATXN7 Antibody

Binding Specificity: Middle Region

Sequence: TRSLTCKTHS LTQRRAVQGR RKRFDVLLAE HKNKTREKEL IRHPDSQQPP

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against ATXN7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATXN7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 892 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ATXN7 antibody (ABIN2777891)

Mu, Lin, Chen, Sung, Bai, Jow: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." in: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).

Target Details for ATXN7

Target: ATXN7 (Ataxin 7 (ATXN7))

Alternative Name: ATXN7

Background: ATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Alias Symbols: ADCAII, OPCA3, SCA7
Protein Interaction Partner: VCP, USP22, PICK1, TP53BP2, RAD23A, ATXN7L3, ENY2, PIAS1, SUMO1, UBE2I, SUMO2, KAT2A, AGRN, LRSAM1, ADAM33, CEP70, COG6, TRIM54, CEP72, RNF31, PPP1R12C, CRIM1, TXNDC11, EFEMP2, UBQLN2, CARD10, NOC2L, NUP62, MPRIP, SPRY1, GPRASP1, PNMA1, RABEP1, KALRN, LTB
Protein Size: 892

Molecular Weight: 95 kDa

Gene ID: 6314

NCBI Accession: NM_000333, NP_000324

UniProt: O15265