T-Box 6 antibody (N-Term)

Catalog No. ABIN2777918

There are 2+ publications for this product available. The Rabbit Polyclonal anti-T-Box 6 antibody is suitable to detect T-Box 6 in samples from Human, Mouse, Rat, Horse, Pig, Cow, Dog and Guinea Pig. It has been validated for WB and IHC.

Quick Overview for T-Box 6 antibody (N-Term) (ABIN2777918)

Target: T-Box 6 (TBX6)

Reactivity: Human, Mouse, Rat, Horse, Pig, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-T-Box 6 Antibody

Binding Specificity: N-Term

Purpose: TBX6 Antibody - N-terminal region

Sequence: AHPPLPLLPP AMGTEPAPSA PEALHSLPGV SLSLENRELW KEFSSVGTEM

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TBX6. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TBX6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8113386

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-T-Box 6 antibody (ABIN2777918)

Chen, Liu, Zhou, Hu, Fei, Xie, Ding: "Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation." in: The Journal of biological chemistry, Vol. 284, Issue 35, pp. 23481-90, (2009) (PubMed).

Leschik, Stefanovic, Brinon, Pucéat: "Cardiac commitment of primate embryonic stem cells." in: Nature protocols, Vol. 3, Issue 9, pp. 1381-7, (2008) (PubMed).

Target Details for T-Box 6

Target: T-Box 6 (TBX6)

Alternative Name: TBX6

Background:

Background Information: The TBX6 gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX6 is the human ortholog of mouse Tbx6. Knockout experiments in mice indicate that Tbx6 is important for specification of paraxial mesoderm structures.

Gene Name: T-box 6

Alternative Symbols: SCDO5

Protein Name: T-box transcription factor TBX6

Molecular Weight: 47kDa

Gene ID: 6911

NCBI Accession: NP_004599

UniProt: O95947