TNKS antibody (Middle Region)

Catalog No. ABIN2778110

This Rabbit Polyclonal antibody specifically detects TNKS in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Horse, Dog and Guinea Pig.

Quick Overview for TNKS antibody (Middle Region) (ABIN2778110)

Target: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Horse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNKS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TNKS Antibody

Binding Specificity: Middle Region

Sequence: LIKGVERLLG GQQGTNPYLT FHCVNQGTIL LDLAPEDKEY QSVEEEMQST

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TNKS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TNKS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1327 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNKS

Target: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Alternative Name: TNKS

Background: TNKS may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. It has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length.
Alias Symbols: PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
Protein Interaction Partner: RNF146, RAPGEF2, TINF2, TNKS, TERF1, SH3BP2, APC, BLZF1, GMDS, UBC, DISC1, TNIK, SH3BP5, TERF2, FANCD2, BABAM1, VPS33A, FNBP1, MCL1, POT1, TNKS2, TNKS1BP1, NUMA1, LNPEP,
Protein Size: 1327

Molecular Weight: 142 kDa

Gene ID: 8658

NCBI Accession: NM_003747, NP_003738

UniProt: O95271