SLC1A2 antibody (N-Term)

Catalog No. ABIN2778148

Cited in 1 publication. The Rabbit Polyclonal anti-SLC1A2 antibody (ABIN2778148) specifically detects SLC1A2 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Sheep samples.

Quick Overview for SLC1A2 antibody (N-Term) (ABIN2778148)

Target: SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC1A2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SLC1A2 Antibody

Binding Specificity: N-Term

Purpose: SLC1A2 Antibody - N-terminal region

Sequence: PGNPKLKKQL GPGKKNDEVS SLDAFLDLIR NLFPENLVQA CFQQIQTVTK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against SLC1A2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC1A2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33840-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-SLC1A2 antibody (ABIN2778148)

Pretto, Kumar, Cao, Cunningham, Durbin-Johnson, Qi, Berman, Noctor, Hagerman, Pessah, Tassone et al.: "Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated ..." in: Neurobiology of aging, Vol. 35, Issue 5, pp. 1189-97, (2014) (PubMed).

Target Details for SLC1A2

Target: SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))

Alternative Name: SLC1A2

Background:

Background Information: SLC1A2 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Solute carrier family 1 (glial high affinity glutamate transporter), member 2

Alternative Symbols: HBGT, DEE41, EAAT2, GLT-1, EIEE41

Protein Name: Excitatory amino acid transporter 2

Molecular Weight: 62kDa

Gene ID: 6506

NCBI Accession: NP_004162

UniProt: P43004

Pathways: Dicarboxylic Acid Transport