ACADL antibody (Middle Region)

Catalog No. ABIN2778159

There is 1 publication for this product available. The Rabbit Polyclonal anti-ACADL antibody is suitable to detect ACADL in samples from Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Zebrafish (Danio rerio) and Guinea Pig. It has been validated for WB.

Quick Overview for ACADL antibody (Middle Region) (ABIN2778159)

Target: ACADL (Acyl-CoA Dehydrogenase, Long Chain (ACADL))

Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACADL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACADL Antibody

Binding Specificity: Middle Region

Purpose: ACADL Antibody - middle region

Sequence: LPQERLLIAD VAISASEFMF EETRNYVKQR KAFGKTVAHL QTVQHKLAEL

Predicted Reactivity: Cow: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against ACADL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ACADL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8093964

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ACADL antibody (ABIN2778159)

Mells, Fu, Sharma, Olson, Cheng, Handy, Saxena, Sorescu, Anania: "Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 2, pp. G225-35, (2012) (PubMed).

Target Details for ACADL

Target: ACADL (Acyl-CoA Dehydrogenase, Long Chain (ACADL))

Alternative Name: ACADL

Background:

Background Information: ACADL belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.

Gene Name: Acyl-CoA dehydrogenase, long chain

Alternative Symbols: LCAD, ACAD4

Protein Name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Molecular Weight: 44kDa

Gene ID: 33

NCBI Accession: NP_001599

UniProt: P28330

Pathways: Monocarboxylic Acid Catabolic Process