TRIM21 antibody (N-Term)

Catalog No. ABIN2778305

This Rabbit Polyclonal antibody specifically detects TRIM21 in WB. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Dog and Rabbit.

Quick Overview for TRIM21 antibody (N-Term) (ABIN2778305)

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM21 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIM21 Antibody

Binding Specificity: N-Term

Sequence: GELRRKQELA EKLEVEIAIK RADWKKTVET QKSRIHAEFV QQKNFLVEEE

Predicted Reactivity: Dog: 77%, Guinea Pig: 92%, Human: 100%, Mouse: 83%, Rabbit: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against TRIM21. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM21

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 475 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Alternative Name: TRIM21

Background: TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM21 is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: RNF81, RO52, SSA, SSA1
Protein Interaction Partner: TRIM39, IGHV4-31, TXN2, GRAP, UBE2I, TRIM21, IGHG1, USP15, HAUS2, UBE2D2, UBC, FBXO6, UBD, NPM1, PAN2, ROR1, NOS2, MYC, IQCB1, USP2, VCP, USP4, CDC34, CBL, UBC4, UBE2C, UBE2L3, UBE2H, UBE2D1, TROVE2, TRIM27, MNAT1, FCGR2A, CD52, DCP2, ZFPM1, TRIM5, TRIM8,
Protein Size: 475

Molecular Weight: 54 kDa

Gene ID: 6737

NCBI Accession: NM_003141, NP_003132

UniProt: P19474