PAX8 antibody (C-Term)

Catalog No. ABIN2778308

This Rabbit Polyclonal antibody specifically detects PAX8 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig and Pig.

Quick Overview for PAX8 antibody (C-Term) (ABIN2778308)

Target: PAX8 (Paired Box 8 (PAX8))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAX8 Antibody

Binding Specificity: C-Term

Purpose: PAX8 Antibody - C-terminal region

Sequence: TPSNTPLGRN LSTHQTYPVV ADPHSPFAIK QETPEVSSSS STPSSLSSSA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PAX8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PAX8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34179-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PAX8

Target: PAX8 (Paired Box 8 (PAX8))

Alternative Name: PAX8

Background:

Background Information: PAX8 is a member of the paired box (PAX) family of transcription factors. Members of this family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in its gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas.

Gene Name: paired box 8

Alternative Symbols: -

Protein Name: Paired box protein Pax-8

Molecular Weight: 48kDa

Gene ID: 7849

NCBI Accession: NP_054698

UniProt: Q06710

Pathways: Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation