ZNF496 antibody (N-Term)

Catalog No. ABIN2778404

The Rabbit Polyclonal anti-ZNF496 antibody (ABIN2778404) specifically detects ZNF496 in WB. The antibody is reactive with Human, Mouse, Cow, Rat, Sheep, Dog, Horse, Pig, Rabbit and Guinea Pig samples.

Quick Overview for ZNF496 antibody (N-Term) (ABIN2778404)

Target: ZNF496 (Zinc Finger Protein 496 (ZNF496))

Reactivity: Human, Mouse, Cow, Rat, Sheep, Dog, Horse, Pig, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF496 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZNF496 Antibody

Binding Specificity: N-Term

Purpose: ZNF496 Antibody - N-terminal region

Sequence: MPTALCPRVL APKESEEPRK MRSPPGENPS PQGELPSPES SRRLFRRFRY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against ZNF496. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ZNF496

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8116682

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZNF496

Target: ZNF496 (Zinc Finger Protein 496 (ZNF496))

Alternative Name: ZNF496

Background:

Background Information: ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.

Gene Name: Zinc finger protein 496

Alternative Symbols: NIZP1, ZFP496, ZSCAN49, ZKSCAN17

Protein Name: Zinc finger protein 496

Molecular Weight: 67kDa

Gene ID: 84838

NCBI Accession: NP_116141

UniProt: Q96IT1