PRMT7 antibody (C-Term)

Catalog No. ABIN2778660

The Rabbit Polyclonal anti-PRMT7 antibody has been validated for WB. It is suitable to detect PRMT7 in samples from Human, Mouse, Rat, Dog, Horse and Guinea Pig.

Quick Overview for PRMT7 antibody (C-Term) (ABIN2778660)

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRMT7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRMT7 Antibody

Binding Specificity: C-Term

Sequence: GEINDQDRTD HYAQALRTVL LPGSVCLCVS DGSLLSMLAH HLGAEQVFTV

Predicted Reactivity: Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against Prmt7. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 692 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRMT7

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Alternative Name: Prmt7

Background: Prmt7 is a arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. It specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. It plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. It may also play a role in embryonic stem cell (ESC) pluripotency. It also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro, the relevance of such results is however unclear in vivo.
Alias Symbols: 4933402B05Rik, BC006705, MGC7929
Protein Interaction Partner: Ctcfl,
Protein Size: 692

Molecular Weight: 78 kDa

Gene ID: 214572

NCBI Accession: NM_145404, NP_663379

UniProt: Q922X9

Pathways: Ribonucleoprotein Complex Subunit Organization