XPO1 antibody (C-Term)

Catalog No. ABIN2778849

Cited in 1 publication. The Rabbit Polyclonal anti-XPO1 antibody (ABIN2778849) specifically detects XPO1 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Zebrafish (Danio rerio), Rabbit, Pig and Saccharomyces cerevisiae samples.

Quick Overview for XPO1 antibody (C-Term) (ABIN2778849)

Target: XPO1 (Exportin 1 (XPO1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Zebrafish (Danio rerio), Rabbit, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-XPO1 Antibody

Binding Specificity: C-Term

Purpose: XPO1 Antibody - C-terminal region

Sequence: NKLGGHITAE IPQIFDAVFE CTLNMINKDF EEYPEHRTNF FLLLQAVNSH

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against XPO1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human XPO1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8100094

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-XPO1 antibody (ABIN2778849)

Kalita, Kapinos, Zheng, Rencurel, Zilman, Lim: "Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage." in: The Journal of cell biology, Vol. 221, Issue 3, (2022) (PubMed).

Target Details for XPO1

Target: XPO1 (Exportin 1 (XPO1))

Alternative Name: XPO1

Background:

Background Information: XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. XPO1 also regulates NFAT and AP-1.The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Exportin 1 (CRM1 homolog, yeast)

Alternative Symbols: emb, CRM1, exp1, CRM-1

Protein Name: Exportin-1

Molecular Weight: 123 kDa

Gene ID: 7514

NCBI Accession: NP_003391

UniProt: O14980

Pathways: M Phase